Professeur Carol Wise

Texas Scottish Rite Hospital for Children, Texas, Etats-Unis
Génétique, Lauréate 2002, 2011, 2024

Carol Wise est directrice du Scottish Rite for Children Center for Translational Research à l’University of Texas Southwestern Medical Center (UTSW).
Ses recherches portent sur l’identification des déterminants génétiques et des mécanismes sous-jacents des troubles musculo-squelettiques pédiatriques.
Elle s’intéresse particulièrement à la scoliose, qui frappe des millions d’enfants dans le monde, en particulier les filles, au cours de leur croissance. Les recherches du Dr Wise ont permis d’identifier de multiples facteurs de risque génétiques pour la scoliose et de mettre en évidence une voie de signalisation sexuellement dimorphique dans le cartilage rachidien.
Elle a également participé à la création du Consortium international pour la génétique, le développement et les maladies de la colonne vertébrale, dans le cadre de son engagement à promouvoir la recherche collaborative sur la scoliose.

Publications

*Gao X, Gordon D, Zhang D, Browne R, Helms C, Gillum J, Weber S, Devroy S, Swaney S, Dobbs M, Morcuende J, Sheffield V, Lovett M, Bowcock A, Herring J, Wise C. CHD7 gene polymorphisms are associated with susceptibility to idiopathic scoliosis. Am J Hum Genet. 2007; 80(5):957-65. PMID: 17436250.

Gao X, Gotway G, Rathjen K, Johnston C, Sparagana S, Rios J, Wise CA. High-density microarray and genomic analyses of patients presenting with unexplained early onset scoliosis, Spine Deformity 2014; 2 (5): 324-32. PMID 25401082.

Sharma S, Londono D, Eckalbar WL, Gao X, Zhang D, Mauldin K, Kou I, Takahashi A, Matsumoto M, Kamiya N, Murphy KK, Cornelia R; TSRHC Scoliosis Clinical Group; Japan Scoliosis Clinical Research Group, Herring JA, Burns D, Ahituv N, Ikegawa S, Gordon D, Wise CA. A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females. Nat Commun. 2015; 6:6452. PMID: 25784220.

*Giampietro PF, Pourquie O, Raggio C, Ikegawa S, Turnpenny PD, Gray R, Dunwoodie SL, Gurnett CA, Alman B, Cheung K, Kusumi K, Hadley-Miller N, Wise CA. Summary of the first inaugural joint meeting of the International Consortium for scoliosis genetics and the International Consortium for vertebral anomalies and scoliosis, March 16–18,2017, Dallas, Texas. Amer J Med Genetics. 2018; 176(1): 253-256. PMID: 29159998.

*Ogura Y, Takeda K, Kou I, Khanshour A, Grauers A, Zhou H, Liu G, Fan YH, Zhou T, Wu Z, Takahashi Y, Matsumoto M; Japan Scoliosis Clinical Research Group (JSCRG); Texas Scottish Rite Hospital for Children Clinical Group (TSRHCCG), Einarsdottir E, Kere J, Huang D, Qiu G, Xu L, Qiu Y, Wise CA, Song YQ, Wu N, Su P, Gerdhem P, Watanabe K, Ikegawa S. An international meta-analysis confirms the association of BNC2 with adolescent idiopathic Scoliosis. Scientific Reports. 2018: 8(1): 4730. PMID: 29549362

Kou I, Watanabe K, Takahashi Y, Momozawa Y, Khanshour A, Grauers A, Zhou H, Liu G, Fan YH, Takeda K, Ogura Y, Zhou T, Iwasaki Y, Kubo M, Wu Z, Matsumoto M, Japan Scoliosis Clinical Research Group, Texas Scottish Rite Hospital for Children Clinical Group, Einarsdottir E, Kere J, Huang D, Qiu G, Qiu Y, Wise CA, Song YQ, Su P, Gerdhem P, Ikegawa S. A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis. Scientific Reports 2018; 8(1):11575. PMID: 30069010.

Khanshour A, Kou I, Fan Y, Einarsdottir E, Makki N, Kidane YH, Kere J, Grauers A, Johnson TA, Paria N, Patel C, Singhania R, Kamiya N, Takeda K, Otomo N, Watanabe K, Luk KDK, Cheung KMC, Herring JA, Rios JJ, Ahituv N, Gerdhem P, Gurnett CA, Song Y, Ikegawa S and Wise CA. Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci. Hum Mol Genet 2018; 27(22): 3986-3998. PMID: 30395268.

Wise CA, Ushiki A, Khanshour A, Kidane YH, Makki N, Gurnett CA, Gray RS, Rios JJ, Ahituv N, Solnica-Krezel L. The cartilage matrisome in adolescent idiopathic scoliosis. Bone Res. 2020;8(13). PMID: 32195011.

Makki N, Zhao J, Liu Z, Eckalbar WL, Ushiki A, Khanshour AM, Wu Z, Gray RS, Wise CA, Ahituv N. Genomic characterization of the adolescent idiopathic scoliosis associated transcriptome and regulome. Hum Mol Genet. 2021; 29(22):3606-3615.PMID: 33179741.

Yu H, Khanshour AM, Ushiki A, Otomo N, Koike Y, Einarsdottir E, Fan Y, Antunes L, Kidane YH, Cornelia T, Sheng R, Zhang Y, Pei J, Grishin NV, Evers BM, Yin Cheung JP, Herring JA, Terao C, Song YQ, Gurnett CA, Gerdhem P, Ikegawa S, Rios JJ, Ahituv N, Wise CA. Association of genetic variation in COL11A1 with adolescent idiopathic scoliosis. eLife. 2024; PMID: 38277211.

Ushiki A, Sheng RR, Zhang Y, Zhao J, Nobuhara M, Murray E, Ruan X, Rios JJ, Wise CA, Ahituv N. Deletion of Pax1 scoliosis-associated regulatory elements leads to a female-biased tail abnormality. Cell Rep. 2024; 43(3):113907. PMID: 38461417.